TFDP1 - transcription factor Dp-1 Gene

Also Known as DP1; DILC; Dp-1; DRTF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7027

About TFDP1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,584,688-113,641,473 (from NCBI)

This gene has 8 transcripts (splice variants), 239 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues.

Summary

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

TFDP1 Products (1)

mRNA Protein Name
NM_007111.5 NP_009042.1 transcription factor Dp-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7739537 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16360038 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7739537 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16360038 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17062573 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
17062573 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7739537 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1531329 GOA
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27825926 GOA
Cellular Component GO Annotation Evidence Références Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
7739537 GOA
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
16360038 GOA
part of Rb-E2F complex IPI
IPI: Inferred from physical interaction
16360038 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17062573 GOA
located in nucleus IDA
IDA: Inferred from direct assay
1531329 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFDP1 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (111 - 193)

DP

DP: Transcription factor DP (200 - 342)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

transcription factor Dp-1

  • DRTF1-polypeptide 1

TFDP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TFDP1 Q14186 NLK Homo sapiens Q9UBE8
Anti Bait CoIP
22773187
Intra
TFDP1 Q14186 E2F1 Homo sapiens Q01094
TAP
24981860
Intra
TFDP1 Q14186 E2F1 Homo sapiens Q01094
TAP
27705803
Intra
TFDP1 Q14186 E2F1 Homo sapiens Q01094
Pull Down
16360038
Intra
TFDP1 Q14186 E2F4 Homo sapiens Q16254
TAP
24981860
Intra
TFDP1 Q14186 E2F4 Homo sapiens Q16254
TAP
27705803
Intra
TFDP1 Q14186 E2F4 Homo sapiens Q16254
Validated Y2H
32296183
Intra
TFDP1 Q14186 E2F4 Homo sapiens Q16254
Y2H Array
32296183
Intra
TFDP1 Q14186 E2F4 Homo sapiens Q16254
Y2H Prey Pooling
32296183
Intra
TFDP1 Q14186 E2F2 Homo sapiens Q14209
TAP
24981860
Intra
TFDP1 Q14186 E2F2 Homo sapiens Q14209
TAP
27705803
Intra
TFDP1 Q14186 DVL1 Homo sapiens O14640
Anti Tag CoIP
22773187
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
Y2H Prey Pooling
32296183
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
TAP
24981860
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
TAP
27705803
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
Validated Y2H
25416956
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
Y2H Array
25416956
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
Y2H Array
32296183
Intra
TFDP1 Q14186 E2F6 Homo sapiens O75461
Y2H Prey Pooling
25416956
Intra
TFDP1 Q14186 MAX Homo sapiens P61244
TAP
24981860
Intra
TFDP1 Q14186 MAX Homo sapiens P61244
TAP
27705803
Intra
TFDP1 Q14186 MAX Homo sapiens P61244
Pull Down
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

TFDP1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P810933 TFDP1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83021 DP1 Antibody (YA2766) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14417 TFDP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21066 Tfdp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27583 Tfdp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TFDP1 RGD RGD:1560344
Macaca mulatta TFDP1 VGNC VGNC:106302
Mus musculus TFDP1 MGD MGI:101934
Felis catus TFDP1 VGNC VGNC:102343
Bos taurus TFDP1 VGNC VGNC:107256
Others TFDP1 NCBI