TAF15 - TATA-box binding protein associated factor 15 Gene

Also Known as Npl3; RBP56; TAF2N; TAFII68

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8148

About TAF15

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,809,484-35,847,242 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 199 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 46.3), lymph node (RPKM 45.2) and 25 other tissues.

Summary

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

TAF15 Products (2)

mRNA	Protein	Name
NM_003487.4	NP_003478.1	TATA-binding protein-associated factor 2N isoform 2
NM_139215.3	NP_631961.1	TATA-binding protein-associated factor 2N isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27378374	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18509338	GOA

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within mRNA stabilization	IDA IDA: Inferred from direct assay	27378374	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19124016	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	19124016	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19124016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF15 Protein Structure

RRM_1

zf-RanBP

0
100
200
300
400
500
589 a.a.

Protein Preferred Names	Protein Names
TATA-binding protein-associated factor 2N	RBP56/CSMF fusion

TAF15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TAF15	Q92804	KAT5	Homo sapiens	Q92993	Pull Down	18509338
Intra	TAF15	Q92804	FUS	Homo sapiens	P35637	Pull Down	23975937
Intra	TAF15	Q92804	FUS	Homo sapiens	P35637	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

TAF15 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82389	TAF15 Antibody (YA2134)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82389A	TAF15 Antibody (YA2134)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83211	TAF1 Antibody (YA2956)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Myxoid Chondrosarcoma
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Liposarcoma	Lipomatous Cancer
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Parachordoma
Extraskeletal Mesenchymal Chondrosarcoma	Mesenchymal Extraosseous Chondrosarcoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1	Ibmpfd1 Msp1 Multisystem Proteinopathy 1
Sclerosing Liposarcoma
Bone Chondrosarcoma
Soft Tissue Chondroma	Extraskeletal Chondroma
Intracranial Chondrosarcoma
Lung Sarcoma	Pulmonary Sarcoma
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14162	TAF15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21778	Taf15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28295	Taf15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAF15	VGNC	VGNC:104662
Rattus norvegicus	TAF15	RGD	RGD:1309595
Felis catus	TAF15	VGNC	VGNC:65926
Bos taurus	TAF15	VGNC	VGNC:54497
Mus musculus	TAF15	MGD	MGI:1917689
Canis familiaris	TAF15	VGNC	VGNC:47076
Others	TAF15	NCBI