Glenvastatin
Glenvastatin (HR 780) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Glenvastatin can reduces plasma total cholesterol and phospholipid levels and liver cholesterol contents. Glenvastatin does not increase the contents of cholesterol and total bile acid in the gallbladder bile. Glenvastatin can be used for the research of hyperlipemia
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- CAS No.: 122254-45-9
- Formule: C27H26FNO3
- Masse moléculaire:431.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
5 nM
Compound: 2i
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Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholesterol.
Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholesterol.
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[PMID: 2296036] |
Chemical Information
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CAS No. 122254-45-9
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Masse moléculaire 431.50
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Formule C27H26FNO3
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SMILES
O[C@@H](CC1=O)C[C@H](O1)/C=C/C2=C(C(C)C)N=C(C3=CC=CC=C3)C=C2C4=CC=C(F)C=C4
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Synonyms
HR 780
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glenvastatin Related Classifications
HY-106380 Related Classifications
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