HDAC-IN-41
Based on 1 publication(s) in Google Scholar
HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity.
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- CAS No.: 2490309-83-4
- Formule: C20H22N4O6S
- Masse moléculaire:446.48
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-41
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Activité biologique
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HDAC1 0.62 μM (IC50) |
HDAC3 0.62 μM (IC50) |
HDAC2 1.46 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.98 μM
Compound: 65
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| HCT-116 | IC50 |
0.77 μM
Compound: 65
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| HEL | IC50 |
0.41 μM
Compound: 65
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Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| HeLa | IC50 |
1.5 μM
Compound: 65
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| Jurkat | IC50 |
0.77 μM
Compound: 65
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Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| MOLT-4 | IC50 |
0.54 μM
Compound: 65
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Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
| PC-3 | IC50 |
2.5 μM
Compound: 65
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Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37487305] |
HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC50 values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2490309-83-4
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Masse moléculaire 446.48
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Formule C20H22N4O6S
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SMILES
O=S(C1=[N+]([O-])ON=C1OCCCCCC(NC2=C(N)C=CC=C2)=O)(C3=CC=CC=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-41 Related Classifications
HY-147840 Related Classifications
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