HDAC3-IN-5
HDAC3-IN-5 (9c) is a HDAC3 selective inhibitor, with IC50 values of 4.2 nM, 1629 nM and 298.2 nM for HDAC3, HDAC2, HDAC1, respectively. HDAC3-IN-5 (9c) can effectively induce apoptosisin MV4-11 cells in vitro and reduce the expression of anti-apoptotic proteins, the development of HDAC3 selective inhibitors may serve as a potential lead compound to reverse Venetoclax resistance.
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- CAS No.: 3095232-95-1
- Formule: C28H38N4O
- Masse moléculaire:446.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HDAC3 4.2 nM (IC50) |
HDAC1 298.2 nM (IC50) |
HDAC2 1629 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
484 nM
Compound: 9c
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Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
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[PMID: 39047608] |
| K562 | IC50 |
383 nM
Compound: 9c
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
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[PMID: 39047608] |
| MV4-11 | IC50 |
315 nM
Compound: 9c
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
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[PMID: 39047608] |
Chemical Information
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CAS No. 3095232-95-1
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Masse moléculaire 446.63
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Formule C28H38N4O
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SMILES
O=C(NNCCC)/C=C/C1=CC=C(CN(CCCC)CCC2=C(C)NC3=C2C=CC=C3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC3-IN-5 Related Classifications
HY-162769 Related Classifications
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