HDAC6-IN-11
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells.
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- CAS No.: 2409072-27-9
- Formule: C19H16N2O4
- Masse moléculaire:336.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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HDAC6 20.7 nM (IC50) |
HDAC8 7750 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| A549 | GI50 |
3.2 μM
Compound: 9
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
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[PMID: 31924504] |
| HCT-116 | GI50 |
1.82 μM
Compound: 9
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Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
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[PMID: 31924504] |
| Sf21 | IC50 |
>10000 nM
Compound: 9
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Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
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[PMID: 31924504] |
In Vitro
HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1].
HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and HCT116 cells
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Concentration:0.44-6.68 μM
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Incubation Time:48 hours
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Result:Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively).
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Cell Line:HCT116 cells
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Concentration:0, 0.6, 1.25, 2.5, 5, 10 and 20 μM
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Incubation Time:48 hours
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Result:Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
Chemical Information
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CAS No. 2409072-27-9
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Masse moléculaire 336.34
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Formule C19H16N2O4
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SMILES
O=C(NO)/C=C/C1=NC2=CC=C(OC3=CC=C(OC)C=C3)C=C2C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-11 Related Classifications
HY-150694 Related Classifications
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