country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183424

Copy Link Print Information

Hydrolapachol

Hydrolapachol is a mitochondrial respiratory chain inhibitor that targets the site between cytochrome b and c₁, and inhibits succinate oxidation in rat liver mitochondria. Hydrolapachol can be used in studies related to mitochondrial respiration.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3343-38-2
Formule: C₁₅H₁₆O₃
Masse moléculaire:244.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hydrolapachol Chemical Structure

CAS No.: 3343-38-2

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	20.46 μM Compound: 7	Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 21115213]
HL-60	IC₅₀	62.13 μM Compound: 13	Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay	[PMID: 17249647]
HL-60	IC₅₀	20.46 μM Compound: 7	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21115213]
MDA-MB-435	IC₅₀	20.46 μM Compound: 7	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 21115213]
PBMC	IC₅₀	20.46 μM Compound: 7	Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay	[PMID: 21115213]
PBMC	IC₅₀	102.34 μM Compound: 3	Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay	[PMID: 21820768]
SF-295	IC₅₀	20.46 μM Compound: 7	Cytotoxicity against human SF295 cells after 72 hrs by MTT assay Cytotoxicity against human SF295 cells after 72 hrs by MTT assay	[PMID: 21115213]

In Vitro

Hydrolapachol inhibits succinate oxidation in intact rat liver mitochondria with an IC₅₀ of 1.6 μg per mg protein^[1].
Hydrolapachol exerts a stronger inhibitory effect on succinate oxidation in intact rat liver mitochondria at lower pH, and this inhibition is completely reversed by bovine serum albumin, CCCP (HY-100941) and 2,4-dibromophenol, and partially reversed by 2,4-dinitrophenol; at low inhibitor concentrations, phosphate (or arsenate) is required to achieve maximal inhibition of succinate oxidation in intact rat liver mitochondria^[1].
Hydrolapachol can be prepared by platinum oxide-platinum black-catalyzed hydrogenation of Isolapachol, and can also be obtained by hydrogenation of lapachol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3343-38-2
Masse moléculaire 244.29
Formule C₁₅H₁₆O₃
SMILES

O=C1C(O)=C(CCC(C)C)C(C2=C1C=CC=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Howland JL. Inhibition of mitochondrial succinate oxidation by alkyl hydroxy naphthoquinones. Biochim Biophys Acta. 1965 Aug 24;105(2):205-13. [Content Brief]

[2]. Hooker SC. Condensation of Aldehydes with β-Hydroxy-α-naphthoquinone. Synthesis of Hydrolapachol. J Am Chem Soc. 1936;58(7):1163-1167.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis