Indaziflam
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Indaziflam is an alkyltriazine herbicide. Indaziflam targets the cellulose synthase complex and inhibits cellulose biosynthesis in plant cell walls. Indaziflam induces radial swelling of plants, ectopic lignification, inhibition of root and hypocotyl elongation, abnormal root and cell morphology, and also induces DNA strand breaks and micronucleus formation in HepG2 cells. Indaziflam can be used for research on monocot weed control.
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- Pureté: 99.83%
- CAS No.: 950782-86-2
- Formule: C16H20FN5
- Masse moléculaire:301.37
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Indaziflam (50-10000 pM; 7 d) potently inhibits growth of light-grown Poa annua (GR50 = 671 pM), light-grown Arabidopsis thaliana (GR50 = 200 pM), and dark-grown Arabidopsis thaliana (GR50 = 214 pM) seedlings, inducing cellulose biosynthesis inhibitor-like symptomologies including radial swelling and ectopic lignification[1].
Indaziflam (200-400 pM; 5 d) dose-dependently reduces crystalline cellulose content in hypocotyls of dark-grown Arabidopsis thaliana seedlings, with 200 pM causing an 18% reduction and 400 pM causing a 51% reduction relative to controls[1].
Indaziflam (50-3200 pM; 0-84 h) inhibits root elongation and growth rate in downy brome, feral rye, Arabidopsis thaliana, and kochia seedlings in a dose-dependent manner, with significantly greater potency on monocots (average GR50 = 231 pM for root length) than dicots (average GR50 = 512 pM for root length)[2].
Indaziflam (200-3200 pM; 84 h) treatment causes cellulose deficiency and distinct morphological abnormalities in the roots of downy brome, feral rye, Arabidopsis thaliana, and kochia, with more severe structural damage observed in monocot roots than dicot roots at equivalent concentrations[2].
Indaziflam (10, 40, 100 μg/mL; 4 h, 24 h) induces dose- and time-dependent DNA strand breaks in HepG2 cells[3].
Indaziflam (10, 40, 100 μg/mL; 4 h, 24 h) induces dose- and time-dependent chromosome damage in HepG2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 950782-86-2
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Appearance Solid
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Masse moléculaire 301.37
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Formule C16H20FN5
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Color White to off-white
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SMILES
N([C@H]1C=2C(C[C@@H]1C)=CC=C(C)C2)C=3N=C(C(C)F)N=C(N)N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (165.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Instruction de manipulation (2659 KB)
Références
[1].
Brabham C, et al. Indaziflam herbicidal action: a potent cellulose biosynthesis inhibitor. Plant Physiol. 2014 Nov;166(3):1177-85.
[Content Brief]
[2]. Sebastian DJ, et al. Indaziflam: a new cellulose-biosynthesis-inhibiting herbicide provides long-term control of invasive winter annual grasses. Pest Manag Sci. 2017;73(10):2149-2162. [Content Brief]
[3]. Könen Adıgüzel S, et al. The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells. Hum Exp Toxicol. 2023;42:9603271231183145. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3182 mL | 16.5909 mL | 33.1818 mL | 82.9545 mL |
| 5 mM | 0.6636 mL | 3.3182 mL | 6.6364 mL | 16.5909 mL | |
| 10 mM | 0.3318 mL | 1.6591 mL | 3.3182 mL | 8.2955 mL | |
| 15 mM | 0.2212 mL | 1.1061 mL | 2.2121 mL | 5.5303 mL | |
| 20 mM | 0.1659 mL | 0.8295 mL | 1.6591 mL | 4.1477 mL | |
| 25 mM | 0.1327 mL | 0.6636 mL | 1.3273 mL | 3.3182 mL | |
| 30 mM | 0.1106 mL | 0.5530 mL | 1.1061 mL | 2.7652 mL | |
| 40 mM | 0.0830 mL | 0.4148 mL | 0.8295 mL | 2.0739 mL | |
| 50 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6591 mL | |
| 60 mM | 0.0553 mL | 0.2765 mL | 0.5530 mL | 1.3826 mL | |
| 80 mM | 0.0415 mL | 0.2074 mL | 0.4148 mL | 1.0369 mL | |
| 100 mM | 0.0332 mL | 0.1659 mL | 0.3318 mL | 0.8295 mL |
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