Isogosferol
Based on 1 publication(s) in Google Scholar
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.
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- CAS No.: 53319-52-1
- Formule: C16H14O5
- Masse moléculaire:286.28
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Activité biologique
Isogosferol (100, 200 µM; 1+16 h) decreases LPS (HY-D1056)-stimulated NO expression in RAW 264.7 cells[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) decreases LPS-stimulated expression of iNOS, COX-2 protein in a dose-dependent manner[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) decreases the LPS-stimulated expression of NF-κB and pERK1/2 in a dose-dependentmanner[1].
Isogosferol (50, 100, 200 µM µM; 1+16 h) decreases LPS-stimulated release of the pro-inflammatory cytokine, IL-1β[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells
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Concentration:100, 200 µM (stimulated with LPS (1 µg/mL))
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Incubation Time:1+16
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Result:Remarkably down-regulated the LPS-stimulated NO expression with an IC50 of 148 μM and shows no effect on cell viability.
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Cell Line:0, 25, 50, 100, 200 µM
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Concentration:1+16
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Incubation Time:1+16
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Result:Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner.
Chemical Information
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CAS No. 53319-52-1
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Masse moléculaire 286.28
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Formule C16H14O5
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SMILES
CC([C@@H](O)COC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O)=C
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Synonyms
(+)-Isogospherol; Isogospherol
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isogosferol Related Classifications
HY-N3480 Related Classifications
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