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ITYR-DBRMD

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.

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CAS No.: 1809339-61-4
Formule: C₁₃H₇Br₂I₂NO₅
Masse moléculaire:670.82

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ITYR-DBRMD Chemical Structure

CAS No.: 1809339-61-4

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Sample (0.1mg)

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(In Japan)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression^[1].

In Vitro

ITYR-DBRMD (Compouund 5) (0.5 μM; 48 h) reduces cell viability in OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

OVCAR3 cells
Concentration:

0.5 μM
Incubation Time:

48 h
Result:

Reduced cell numbers by microscopy.

In Vivo

ITYR-DBRMD (Compound 5) (5 mg/kg; i.c.v.; continuous infusion via osmotic minipump) reduces the latency to feed in the novelty suppressed feeding test in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 8 weeks old)^[1]
Dosage:

5 mg/kg
Administration:

i.c.v.; continuous infusion via osmotic minipump
Result:

Reduced the latency to feed in the novelty suppressed feeding test.

Chemical Information

CAS No. 1809339-61-4
Masse moléculaire 670.82
Formule C₁₃H₇Br₂I₂NO₅
SMILES

O=C(C(CC1=CC(I)=C(C(I)=C1)O)N2C(C(Br)=C(C2=O)Br)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bernard Lerer, et al. Type iii deiodinase inhibitors and uses thereof. WO2015140792. 2016-09-16

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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