JAMI1001A
JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.
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- CAS No.: 1001019-46-0
- Formule: C16H17F3N4O3S
- Masse moléculaire:402.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
JAMI1001A binds in the solvent accessible allosteric pocket that lies at the interface between AMPA receptor ligand-binding core dimers. JAMI1001A efficaciously blocks channel desensitization and slows deactivation of the flip and flop isoforms of AMPA receptor GluA2[1].
A simple kinetic model suggests that JAMI1001A independently modulates both the protein rearrangements necessary for channel desensitization and its recovery from the desensitized state, and the protein rearrangements necessary for channel deactivation (closed-cleft stability or channel gating)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1001019-46-0
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Masse moléculaire 402.39
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Formule C16H17F3N4O3S
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SMILES
O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C(CO)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAMI1001A Related Classifications
HY-124906 Related Classifications
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