JMF4073
JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC50s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo.
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- CAS No.: 1927930-61-7
- Formule: C18H22FN3O4S
- Masse moléculaire:395.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
WT-Bcr-Abl cells are highly susceptible to JMF4073 with GI50 0.67 μM as compared to 1.5 μM and 4.2 μM for T315I-Bcr-Abl-32D and untransformed 32D cells, respectively. The levels of overall tyrosine phosphorylation in these cells were unaffected by JMF4073 treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H/HeNCrNarl mice injected with WT-Bcr-Abl-32D chronic myeloid leukemia (CML) cells[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily; for 14 days
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Result:Prolonged the survival of leukemia mice.
Chemical Information
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CAS No. 1927930-61-7
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Masse moléculaire 395.45
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Formule C18H22FN3O4S
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SMILES
FC1=CC=C(SN(CC(N2CCN(C(OC(C)(C)C)=O)CC2)=O)C3=O)C3=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMF4073 Related Classifications
HY-162698 Related Classifications
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