JMS-038
JMS-038 is a PTP4A3 inhibitor with an IC50 of 0.018 μM against human PTP4A3. JMS-038 can be used in ovarian cancer-related research.
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- CAS No.: 86126-60-5
- Formule: C12H8N2O2S
- Masse moléculaire:244.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hPTP4A3 0.018 μM (IC50) |
In Vitro
JMS-038 (Compound 21) is a PTP4A3 inhibitor. PTP4A3 is an oncogenic dual-specificity protein tyrosine phosphatase whose core functions are to drive tumor proliferation, migration and metastasis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 86126-60-5
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Masse moléculaire 244.27
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Formule C12H8N2O2S
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SMILES
O=C1NC(C2=C(N1)SC(C3=CC=CC=C3)=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Salamoun JM, et al. Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Org Biomol Chem. 2016;14(27):6398-6402. [Content Brief]
[2]. McQueeney KE, et al. Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor. Oncotarget. 2017;9(9):8223-8240. Published 2017 Dec 30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMS-038 Related Classifications
HY-183953 Related Classifications
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