L-Lactaldehyde
L-Lactaldehyde ((2S)-Hydroxypropanal) is a chiral aldehyde, metabolic intermediate, and enzyme substrate. L-Lactaldehyde is oxidized to L-lactate by NAD-dependent lactaldehyde dehydrogenase. L-Lactaldehyde is reduced to L-1,2-propanediol by NADH/NADPH-dependent oxidoreductases. L-Lactaldehyde is used in studies of microbial sugar metabolism and carbonyl metabolism.
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- CAS No.: 3913-64-2
- Formule: C3H6O2
- Masse moléculaire:74.08
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Purified dog liver dimeric dihydrodiol dehydrogenase reduces L-Lactaldehyde ((2S)-Hydroxypropanal), with a Km value of 0.67 mM, a Vmax value of 1.15 units/mg, and a Vmax/Km ratio of 1.7 units/mg/mM[1].
L-Lactaldehyde is an NADH-dependent substrate of Escherichia coli propanediol oxidoreductase, which can be reduced to L-1,2-propanediol. Its Km is 0.035 mM, Vmax is 20 μmol/min/mg, and the optimal pH for the reaction is 6.5[2].
L-Lactaldehyde acts as a stereoselective substrate for Saccharomyces cerevisiae NAD-dependent lactaldehyde dehydrogenase, which oxidizes it to L-lactate with a Km of 10 mM, whereas the activity of D-lactaldehyde is only 0.2% that of L-Lactaldehyde[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3913-64-2
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Masse moléculaire 74.08
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Formule C3H6O2
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SMILES
O=C[C@@H](O)C
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Synonyms
(2S)-Hydroxypropanal
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sato K, et al. Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver. Journal of biochemistry. 1994 Sep;116(3):711-7. [Content Brief]
[2]. Boronat A, et al. Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme. Journal of bacteriology. 1979 Nov;140(2):320-6. [Content Brief]
[3]. Inoue Y, et al. Metabolism of 2-oxoaldehydes in yeasts. Purification and characterization of lactaldehyde dehydrogenase from Saccharomyces cerevisiae. European journal of biochemistry. 1985 Dec 02;153(2):243-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Lactaldehyde Related Classifications
HY-184860 Related Classifications
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- L-Lactaldehyde
- 3913-64-2
- (2S)-Hydroxypropanal
- Endogenous Metabolite
- Saccharomyces cerevisiae
- lactaldehyde dehydrogenase
- dehydrogenases
- methylglyoxal reductase
- Escherichia coli K-12 strain 1
- Escherichia coli
- L-specific oxidoreductases
- dihydrodiol dehydrogenase
- propanediol oxidoreductase
- L-lactate
- Inhibitor
- inhibitor
- inhibit