L-Serine-15N
Based on 1 Customer Validation
L-Serine-15N is the 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- Pureté : 99.9%
- CAS No.: 59935-32-9
- Formule: C3H715NO3
- Masse moléculaire:106.09
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 59935-32-9
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Unlabeled CAS 56-45-1
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Appearance Solid
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Masse moléculaire 106.09
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Formule C3H715NO3
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Color White to off-white
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SMILES
OC([C@@H]([15NH2])CO)=O
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Synonyms
(-)-Serine-15N; (S)-Serine-15N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
H2O : 50 mg/mL (471.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.4260 mL | 47.1298 mL | 94.2596 mL | 235.6490 mL |
| 5 mM | 1.8852 mL | 9.4260 mL | 18.8519 mL | 47.1298 mL | |
| 10 mM | 0.9426 mL | 4.7130 mL | 9.4260 mL | 23.5649 mL | |
| 15 mM | 0.6284 mL | 3.1420 mL | 6.2840 mL | 15.7099 mL | |
| 20 mM | 0.4713 mL | 2.3565 mL | 4.7130 mL | 11.7824 mL | |
| 25 mM | 0.3770 mL | 1.8852 mL | 3.7704 mL | 9.4260 mL | |
| 30 mM | 0.3142 mL | 1.5710 mL | 3.1420 mL | 7.8550 mL | |
| 40 mM | 0.2356 mL | 1.1782 mL | 2.3565 mL | 5.8912 mL | |
| 50 mM | 0.1885 mL | 0.9426 mL | 1.8852 mL | 4.7130 mL | |
| 60 mM | 0.1571 mL | 0.7855 mL | 1.5710 mL | 3.9275 mL | |
| 80 mM | 0.1178 mL | 0.5891 mL | 1.1782 mL | 2.9456 mL | |
| 100 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3565 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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