Lecimibide
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
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- CAS No.: 130804-35-2
- Formule: C34H40F2N4OS
- Masse moléculaire:590.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
1000 nM
Compound: 1
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Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
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[PMID: 7707310] |
| Macrophage | IC50 |
1 μM
Compound: table I
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Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
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10.1016/0960-894X(95)00001-A |
| Macrophage | IC50 |
1 μM
Compound: DuP-128
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Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
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10.1016/0960-894X(95)00003-C |
In Vitro
Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 130804-35-2
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Masse moléculaire 590.77
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Formule C34H40F2N4OS
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SMILES
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
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Synonyms
DuP 128
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lecimibide Related Classifications
HY-16281 Related Classifications
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