LLP-3
Based on 1 Customer Validation
LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.13%
- CAS No.: 1453835-43-2
- Formule: C32H23ClN2O4
- Masse moléculaire:534.99
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Survivin[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LN-229 | IC50 |
31.2 μM
Compound: 10; LLP3
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Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition
Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition
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[PMID: 38092421] |
LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins[1].
LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells[1].
LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death[1].
LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells[1].
LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87E6, U87MG cell
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Concentration:0-100 μM
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Incubation Time:72 h
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Result:Inhibited tumor cells survival with IC50 values of 13.6 μM (U87E6) and 38.1 μM (U87MG).
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Cell Line:U87 cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Reduced the proportions of cells in the S and G2-M phases (from 9% to 5%, and from 25% to 17%, respectively).
Increased G0-G1 cell population (from 60% to 74%).
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Cell Line:U87, HT1080 cells
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Concentration:40 μM
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Incubation Time:24 h
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Result:Weakened the colocalization of TPX2 with the acetylated α-tubulin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:GBM sphere-derived tumor models (GBM83 and 1600)[1]
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Dosage:25 mg/kg
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Administration:Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
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Result:Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
Chemical Information
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CAS No. 1453835-43-2
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Appearance Solid
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Masse moléculaire 534.99
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Formule C32H23ClN2O4
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Color White to light yellow
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SMILES
N#CC1=C(C2=CC(OCC3=CC=CC=C3)=CC(OCC4=CC=CC=C4)=C2)C=C(C5=CC(Cl)=CC=C5O)NC1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 12.5 mg/mL (23.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8692 mL | 9.3460 mL | 18.6919 mL | 46.7298 mL |
| 5 mM | 0.3738 mL | 1.8692 mL | 3.7384 mL | 9.3460 mL | |
| 10 mM | 0.1869 mL | 0.9346 mL | 1.8692 mL | 4.6730 mL | |
| 15 mM | 0.1246 mL | 0.6231 mL | 1.2461 mL | 3.1153 mL | |
| 20 mM | 0.0935 mL | 0.4673 mL | 0.9346 mL | 2.3365 mL |
LLP-3 Related Classifications
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