LW-216
LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.
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- CAS No.: 2146090-18-6
- Formule: C30H31NO5
- Masse moléculaire:485.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.1 μM
Compound: 18l
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Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| B16 | IC50 |
3.21 μM
Compound: 18l
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Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| HepG2 | IC50 |
4.66 μM
Compound: 18l
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Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
| MCF7 | IC50 |
1.89 μM
Compound: 18l
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Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 28987604] |
In Vitro
LW-216 (5-25 μM, 24 h) selectively downregulates TrxR1 protein levels and induce apoptosis in NCI-H460 and A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H460, A549
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Concentration:5, 15, 25 μM
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Incubation Time:24 h
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Result:Reduced TrxR1 expression in both cell lines.
Decreased the protein level of Bcl-2, PARP1 and Caspase-9, while increased Bax.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCI-H460 cells in a xenograft mice model[1]
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Dosage:8 mg/kg, once every two days for 18 days
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Administration:i.v.
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Result:Reduced bioluminescence intensity.
Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.
Chemical Information
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CAS No. 2146090-18-6
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Masse moléculaire 485.57
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Formule C30H31NO5
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LW-216 Related Classifications
HY-163724 Related Classifications
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