MD08-1
MD08 is an inhibitor of Aβ42 fibrillization and Tau aggregation. MD08 improves recognition memory and learning/memory abilities in Aβ-induced cognitive decline mouse models. MD08 does not impair motor coordination in Aβ-injected mice. MD08 has no anticancer activity against neuroblastoma. MD08 can be used for research on Alzheimer's disease.
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- Formule: C21H20Br2N2O3
- Masse moléculaire:508.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
MD08 (50 μM; 5 h) suppresses Aβ42 fibril formation, as shown by reduced and smaller aggregates in TEM images[1].
MD08 (100-200 μM; 72 h) inhibits heparin-induced tau aggregation in a concentration-dependent manner, reaching approximately 75% inhibition at 200 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:50 μM
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Incubation Time:24 h
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Result:Did not exhibit any significant cytotoxic effects compared with the control group.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino (25-40 g)[1]
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Dosage:2 mg/kg, 5 mg/kg, and 10 mg/kg
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Administration:i.p.; 14 days
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Result:In the elevated plus maze test, % ITL was reduced to approximately 45% at 2 mg/kg, approximately 40% at 5 mg/kg, and 25% at 10 mg/kg.
In the novel object recognition test, the 2 mg/kg dose did not improve the discrimination index, while 5 mg/kg and 10 mg/kg produced higher discrimination index values.
In the rotarod test, 10 mg/kg did not impair motor coordination.
Chemical Information
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Masse moléculaire 508.20
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Formule C21H20Br2N2O3
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SMILES
BrC1=CC=C(Br)C(CCC(C(NCCC2=CNC3=C2C=C(OC)C=C3)=O)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MD08-1 Related Classifications
HY-190448 Related Classifications
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