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Cat. No.: HY-113885

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MDA77

Name: MDA77
Brand: MedChemExpress
SKU: HY-113885
Price: 294.00 USD
Availability: InStock
Rating: 5 (1 reviews)

MDA77 is a CB2 inverse agonist with an EC₅₀ of 5.82 nM, showing selectivity for human CB2 and no activity on CB1.

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CAS No.: 1103774-21-5
Formule: C₂₁H₂₃N₃O₃
Masse moléculaire:365.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

MDA77 Chemical Structure

CAS No.: 1103774-21-5

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Fluorescent Dye

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

MDA77 is a CB2 inverse agonist with an EC₅₀ of 5.82 nM, showing selectivity for human CB2 and no activity on CB1^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	263 nM Compound: 16, MDA77	Inverse agonist activity at human recombinant CB1 receptor expressed CHO cells membrane by [35S]GTPgamma binding assay Inverse agonist activity at human recombinant CB1 receptor expressed CHO cells membrane by [35S]GTPgamma binding assay	[PMID: 19115816]
CHO	EC₅₀	5.8 nM Compound: 16, MDA77	Inverse agonist activity at human recombinant CB2 receptor expressed CHO cells membrane by [35S]GTPgamma binding assay Inverse agonist activity at human recombinant CB2 receptor expressed CHO cells membrane by [35S]GTPgamma binding assay	[PMID: 19115816]

Chemical Information

CAS No. 1103774-21-5
Masse moléculaire 365.43
Formule C₂₁H₂₃N₃O₃
SMILES

O=C(N/N=C1C(N(CCCCC)C2=C\1C=CC(OC)=C2)=O)C3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Philippe Diaz, et al. 6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction. J Med Chem. 2009 Jan 22;52(2):433-44. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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MDA77

Voir tous les produits spécifiques à Isoform Cannabinoid Receptor