mGluR5 modulator 1

mGluR5 modulator 1 (compound 2c; 0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses to the same maximum response as the orthosteric agonists alone in the Ca²⁺ mobilization and IP1 accumulation assays^[1].
mGluR5 modulator 1 (0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses above the orthosteric agonist maximal response in the ERK1/2 phosphorylation assay^[1].
mGluR5 modulator 1 induces mGlu5 internalization in the absence of add orthosteric agonist or antagonist^[1].
mGluR5 modulator 1 potentiates the responses induced by both orthosteric agonists (L-glutamate or DHPG) in Ca²⁺ mobilization (pK_B=5.4 and 5.3, respecyively), inositol monophosphate accumulation, and ERK1/2 phosphorylation signaling (pK_B=5.88 and 5.4, respecyively) assays in HEK293A-mGlu₅-low cells^[1].
mGluR5 modulator 1 enhances the effect of DHPG in cortical neurons with pEC₅₀ values of 6.32 and 6.33 in Ca²⁺ mobilization and inositol monophosphate (IP1) accumulation assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.