MK-4541
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model.
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- CAS No.: 796885-38-6
- Formule: C22H31F3N2O3
- Masse moléculaire:428.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MK-4541 (100 mg/kg, 200 mg/kg; p.o.; 5 times per week for 5 weeks) exhibits anti-androgen effects on the seminal vesicles, reduces plasma testosterone concentrations in intact males, and inhibits Ki67 expression[1].
MK-4541 (15 mg/kg, 50 mg/kg; p.o.; 5 times per week for 8 weeks) causes the loss of musculoskeletal mass and function in adult castrated mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:R3327-G prostate tumors in xenograft mouse model[1]
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Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg
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Administration:Oral gavage; once daily, 5 times per week for 5 weeks
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Result:Significantly inhibited tumor growth at 100 mg/kg, as well as reducing plasma testosterone concentration and Ki67 expression.
Chemical Information
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CAS No. 796885-38-6
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Masse moléculaire 428.49
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Formule C22H31F3N2O3
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])N(C(C=C2)=O)C)([H])[C@@]4([H])[C@@](C)([C@@H](NC(OCC(F)(F)F)=O)CC4)CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-4541 Related Classifications
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