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Cat. No.: HY-P99744

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Biologically Validated

Modakafusp alfa

(Synonyms: TAK-573)

Avis client

Based on 1 Customer Validation

Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to CD38-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 96.22%
CAS No.: 2254522-19-3
Masse moléculaire:183.48 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Modakafusp alfa Chemical Structure

CAS No.: 2254522-19-3

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- In Vitro
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

In Vitro

Modakafusp alfa (24 h) rapidly activates NK cells, and improves their degranulation and anti- multiple myeloma (MM) effectivity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Modakafusp alfa shows immunomodulatory and antitumor activity in IFNα-insensitive, immunocompetent murine multiple myeloma tumor models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Modakafusp alfa can bind Human CD38 Protein (ECD, His Tag). The EC₅₀ for this effect is 2.553 ng/mL.
Immobilized Modakafusp alfa can bind Anti-Interferon alpha 2/IFNA2 Antibody. The EC₅₀ for this effect is 14.45 ng/mL.

Chemical Information

CAS No. 2254522-19-3
Appearance Liquid
Masse moléculaire 183.48 kDa
Color Colorless to light yellow
SMILES

[Modakafusp alfa]
Synonyms

TAK-573
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Dan T. Vogl MD, et al. TAK-573, an Anti-CD38/Attenuated Ifnα Fusion Protein, Has Clinical Activity and Modulates the Ifnα Receptor (IFNAR) Pathway in Patients with Relapsed/Refractory Multiple Myeloma.Blood. 2020, 136 (1), 37-38.

[2]. Fatholahi M, et al. TAK-573, an anti-CD38-targeted attenuated interferon alpha (IFNα) fusion protein, showed anti-myeloma tumor responses in combination with standard of care (SOC) agents in multiple myeloma (MM) xenograft tumor models in vivo[J]. Clinical Lymphoma, Myeloma and Leukemia, 2019, 19(10): e116.

[3]. Hara T, et al. A murine reactive version of TAK-573 (anti-CD38 attenuated IFNα fusion protein) shows immunomodulatory and antitumor activity, alone and in combination with standard-of-care agents, in IFNa-insensitive, immunocompetent murine multiple myeloma tumor models[J]. Cancer Research, 2020, 80(16_Supplement): 5546-5546.

[4]. Bruins W S C, et al. Modakafusp alfa (TAK-573), a novel CD38-targeting attenuated interferon-alpha immunocytokine, kills MM cells via NK cell activation[J]. Blood, 2022, 140(Supplement 1): 4236-4237.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- In Vitro
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

1/16

Human IgG4 kappa
1/16

Immobilized Modakafusp alfa can bind Human CD38 Protein (ECD, His Tag). The EC₅₀ for this effect is 2.553 ng/mL.
1/16

Immobilized Modakafusp alfa can bind Anti-Interferon alpha 2/IFNA2 Antibody. The EC₅₀ for this effect is 14.45 ng/mL.
1/16

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Modakafusp alfa

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Modakafusp alfa Related Classifications

HY-P99744 Related Classifications