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Cat. No.: HY-185917

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N2-MIE-dG

N2-MIE-dG is the major DNA adduct formed after the activation of methyleugenol (ME) by SULT. N2-MIE-dG serves as a key biomarker for genotoxicity, metabolic activation, and potential carcinogenic risk.

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CAS No.: 1399244-45-1
Formule: C₂₁H₂₅N₅O₆
Masse moléculaire:443.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

N2-MIE-dG Chemical Structure

CAS No.: 1399244-45-1

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Activité biologique

Description

Voir tous les produits spécifiques à Isoform SULT :

SULT1

In Vitro

Under mutagenicity testing conditions, N2-MIE-dG is the predominant adduct formed in SULT-expressing *Salmonella typhimurium*^[1].
N2-MIE-dG is abundantly formed in herring sperm DNA incubated with (±)-1'-acetoxymethyleugenol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1399244-45-1
Masse moléculaire 443.45
Formule C₂₁H₂₅N₅O₆
SMILES

O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)NC(NC/C=C/C4=CC=C(OC)C(OC)=C4)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Herrmann K, et al. Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods. Mutagenesis. 2012 Jul;27(4):453-62. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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N2-MIE-dG

Voir tous les produits spécifiques à Isoform SULT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

N2-MIE-dG Related Classifications

HY-185917 Related Classifications