Nordentatin
Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein Mcl-1 and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma.
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- CAS No.: 1083193-15-0
- Formule: C19H20O4
- Masse moléculaire:312.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Caspase 3 |
Mcl-1 |
MMP-9 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
8.7 μg/mL
Compound: 2
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Cytotoxicity against human A549 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human A549 cells after 3 days by sulforhodamine B assay
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[PMID: 19635670] |
Chemical Information
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CAS No. 1083193-15-0
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Masse moléculaire 312.36
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Formule C19H20O4
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SMILES
O=C1OC2=C(C(O)=C3C=CC(C)(C)OC3=C2C(C)(C)C=C)C=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sunthitikawinsakul A, et al. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Planta Med. 2003 Feb;69(2):155-7. [Content Brief]
[2]. Boonyarat C, et al. Nordentatin Inhibits Neuroblastoma Cell Proliferation and Migration through Regulation of GSK-3 Pathway. Curr Issues Mol Biol. 2022 Feb 24;44(3):1062-1074. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nordentatin Related Classifications
HY-N16746 Related Classifications
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