OHM1
OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1450995-09-1
- Formule: C24H42N6O5
- Masse moléculaire:494.63
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
OHM1 (1-20 μM; 24 h) results in a dose-dependent reduction in the HIF promoter activity, and reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 μM in MDA-MB-231 cells[1].
OHM1 down-regulates hypoxia-inducible gene expression[1].
OHM1 (10 μM) down-regulates multiple genes implicated in angiogenesis, apoptosis, cell proliferation, and invasion, along with several cancer-specific markers in the A549 non-small-cell lung cancer cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549
-
Concentration:10 μM
-
Incubation Time:24 h
-
Result:Down-regulated the mRNA expression levels of the critical angiogenesis regulator vascular endothelial growth factor (VEGFA) by 80%. Decreased lysyl oxidase (LOX) and glucose transporter 1 (GLUT1) expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c mice, MDA-MB-231 xenograft model[1]
-
Dosage:15 mg/kg
-
Administration:Intraperitoneal injection, every other day for 15 injections
-
Result:Reduced the median tumor volume by roughly 50% compared with the untreated group. Did not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals, nor increased the metastasis rate.
Chemical Information
-
CAS No. 1450995-09-1
-
Masse moléculaire 494.63
-
Formule C24H42N6O5
-
SMILES
O=C(N)[C@@H](N1C([C@H](C)N(C([C@@H](N2C([C@H](CC(C)C)NCC2)=O)CC(C)C)=O)CC1)=O)CCC(N)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OHM1 Related Classifications
HY-124722 Related Classifications
Powered by Bioz