OX2-2303
OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research.
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- CAS No.: 1607428-33-0
- Formule: C23H21FN4O2S
- Masse moléculaire:436.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Voir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor)
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Activité biologique
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OX2 Receptor 0.1 nM (Ki) |
OX2-2303 (compound 1) exhibits no significant off-target activity across a panel of 59 major CNS targets, with exception of low affinity binding to sigma-2 (Ki = 2681 nM) and NR2B receptors (Ki = 9475 nM)[1].
OX2-2303 shows favorable tracer integrity, with no appreciable radiometabolites detected in saline, serum (mouse, rat, nonhuman primate, and human), and liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1607428-33-0
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Masse moléculaire 436.50
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Formule C23H21FN4O2S
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SMILES
FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OX2-2303 Related Classifications
HY-178871 Related Classifications
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