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Cat. No.: HY-180526

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PDE2A-IN-2

PDE2A-IN-2 is a selective and brain-penetrant PDE2A inhibitor (K_i = 5.49 nM and 100 > fold selectivity over other PDE isoforms). The ¹¹C-labeled PDE2A-IN-2 serves as a positron emission tomography (PET) tracer for brain imaging in patients with neurodegenerative diseases. PDE2A-IN-2 educes the radiotracer signal in PDE2A-rich regions in vitro. PDE2A-IN-2 exhibits low binding affinity in vivo. PDE2A-IN-2 can be used for neurodegenerative diseases .

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CAS No.: 2055901-03-4
Formule: C₁₇H₁₆F₃N₅
Masse moléculaire:347.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PDE2A-IN-2 Chemical Structure

CAS No.: 2055901-03-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target^[1]

PDE2A

5.49 nM (Ki)

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

In Vitro

PDE2A-IN-2 (compound 1) (1 μM, 30 min) reduces the radiotracer signal in PDE2A-rich regions, leading to a more homogeneous distribution in SD rat brain sections when co-treated with its unlabeled form (1 μM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PDE2A-IN-2 (compound 1) (1 mg/kg, i.v., once) exhibits low binding affinity in SD rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SD rat^[1]
Dosage:

1 mg/kg
Administration:

i.v., once
Result:

Led to similar TAC patterns and regional brain distributions to baseline.

Chemical Information

CAS No. 2055901-03-4
Masse moléculaire 347.34
Formule C₁₇H₁₆F₃N₅
SMILES

CC1=NC2=C(C(NC3(C4=CC=C(C=C4)C(F)(F)F)CC3)=N1)C=NN2C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li Y, et al. Radiosynthesis and Preclinical Evaluation of a Novel 11C Labeled Pyrazolopyrimidine Derivative for Positron Emission Tomography Imaging of Phosphodiesterase 2A. ACS Med Chem Lett. 2025 Dec 12;17(1):218-225. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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PDE2A-IN-2

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PDE2A-IN-2 Related Classifications

HY-180526 Related Classifications