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Cat. No.: HY-P12013

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PEG12KL4

PEG12KL4 is a PEG-modified amphipathic cell-penetrating peptide. PEG12KL4 promotes the transfection and delivery of mRNA into lung cells, maintains mRNA stability, and forms mRNA complexes that retain integrity and translatability. PEG12KL4 endows lipid nanoparticles (LNPs) with anti-nebulization properties, enhances transfection efficiency in artificial mucus when used in combination with LNPs, and enables the formation of dry powder formulations with low toxicity and mild inflammatory responses. PEG12KL4 can be used in studies related to drug delivery for pulmonary diseases (cystic fibrosis, chronic obstructive pulmonary disease).

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Formule: C₁₅₃H₂₉₁N₂₇O₃₅
Masse moléculaire:3069.11

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PEG12KL4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

PEG12KL4 (1.5-40 mol%; at least 30 min)-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain stable hydrodynamic size, polydispersity index, zeta potential, and encapsulation efficiency following nebulisation^[1].
PEG12KL4-containing LNPs with 10 mol% PEG12KL4 (P10NP3) maintain consistent mRNA transfection efficiency in A549 cells following nebulisation^[1].
PEG12KL4 forms stable mRNA complexes that can be processed into dry powder aerosols via spray drying and spray freeze drying while preserving mRNA integrity and translational capability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 3069.11
Formule C₁₅₃H₂₉₁N₂₇O₃₅
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O
Sequence

PEG12-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-NH2
Sequence Shortening

PEG12-KLLLLKLLLLKLLLLKLLLLK-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ma C. The combination of PEG12KL4 peptide and lipid nanoparticles (LNPs) for pulmonary mRNA delivery via nebulisation. DDL2025, 2025.

[2]. Yokoo H, et al. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery. Pharmaceutics. 2021 Dec 29;14(1):78. [Content Brief]

[3]. He X, et al. Nonviral targeted mRNA delivery: principles, progresses, and challenges. MedComm. 2025 Jan;6(1):e70035. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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