Petatewalide A
Petatewalide A is a bakkenolide-type sesquiterpene. Petatewalide A is isolated from Petasites tatewakianus. Petatewalide A inhibits NO production. Petatewalide A exhibits anticancer activity against cervical cancer, breast cancer, and Lewis lung cancer.
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- CAS No.: 1280717-80-7
- Formule: C22H30O6
- Masse moléculaire:390.48
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Stockage:
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
93.3 μM
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Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound.
Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound.
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19686812 |
| MCF7 | IC50 |
114.3 μM
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Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound.
Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound.
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19686812 |
| BV-2 | IC50 |
84.1 μM
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Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs.
Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs.
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25188451 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1280717-80-7
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Masse moléculaire 390.48
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Formule C22H30O6
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SMILES
O(C(C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=C(C)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Dong XW, et al. Bakkenolides from Petasites tatewakianus. Fitoterapia. 2010 Apr;81(3):153-6. [Content Brief]
[2]. Wang M, et al. Characterization and NO inhibitory activities of chemical constituents from an edible plant Petasites tatewakianus. Journal of agricultural and food chemistry. 2014 Sep 24;62(38):9362-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Petatewalide A Related Classifications
HY-N21762 Related Classifications
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