PF-6683324
Based on 1 Customer Validation
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.
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- Pureté: 99.41%
- CAS No.: 1799788-94-5
- Formule: C24H23F4N5O4
- Masse moléculaire:521.46
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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TrkA 1.9 nM (IC50, in cell-based assays) |
TrkB 2.6 nM (IC50, in cell-based assays) |
TrkC 1.1 nM (IC50, in cell-based assays) |
PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1799788-94-5
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Appearance Solid
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Masse moléculaire 521.46
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Formule C24H23F4N5O4
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Color Off-white to light yellow
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SMILES
O=C(N)C1=C(O[C@H]2CCN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C[C@H]2F)N=CC(C4=CN(C)C=N4)=C1
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Synonyms
Trk-IN-4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : ≥ 100 mg/mL (191.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9177 mL | 9.5885 mL | 19.1769 mL | 47.9423 mL |
| 5 mM | 0.3835 mL | 1.9177 mL | 3.8354 mL | 9.5885 mL | |
| 10 mM | 0.1918 mL | 0.9588 mL | 1.9177 mL | 4.7942 mL | |
| 15 mM | 0.1278 mL | 0.6392 mL | 1.2785 mL | 3.1962 mL | |
| 20 mM | 0.0959 mL | 0.4794 mL | 0.9588 mL | 2.3971 mL | |
| 25 mM | 0.0767 mL | 0.3835 mL | 0.7671 mL | 1.9177 mL | |
| 30 mM | 0.0639 mL | 0.3196 mL | 0.6392 mL | 1.5981 mL | |
| 40 mM | 0.0479 mL | 0.2397 mL | 0.4794 mL | 1.1986 mL | |
| 50 mM | 0.0384 mL | 0.1918 mL | 0.3835 mL | 0.9588 mL | |
| 60 mM | 0.0320 mL | 0.1598 mL | 0.3196 mL | 0.7990 mL | |
| 80 mM | 0.0240 mL | 0.1199 mL | 0.2397 mL | 0.5993 mL | |
| 100 mM | 0.0192 mL | 0.0959 mL | 0.1918 mL | 0.4794 mL |
PF-6683324 Related Classifications
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