Pifithrin-β
Based on 21 publication(s) in Google Scholar
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
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- CAS No.: 60477-34-1
- Formule: C16H16N2S
- Masse moléculaire:268.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Pifithrin-β
More- Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]
- J Immunother Cancer. 2026 Feb 24;14(2):e013655. [Abstract]
- Cell Commun Signal. 2022 Sep 5;20(1):96. [Abstract]
- Int J Mol Med. 2021 Jul;48(1):122. [Abstract]
- Cancer Cell Int. 2023 Sep 28;23(1):221. [Abstract]
- Front Bioeng Biotechnol. 2020 Feb 20:8:75. [Abstract]
- Life Sci. 2021 Sep 1:280:119698. [Abstract]
- Cell Biol Toxicol. 2023 Oct;39(5):2011-2032. [Abstract]
- Int J Mol Sci. 2023 Jul 17;24(14):11554. [Abstract]
- mBio. 2024 Dec 11;15(12):e0213724. [Abstract]
- Front Cell Dev Biol. 2020 Jul 29:8:703. [Abstract]
- Sci Rep. 2025 Sep 29;15(1):33534. [Abstract]
- iScience. 2024 Jun 4;27(7):110144. [Abstract]
- Front Mol Biosci. 2021 Aug 19;8:697457. [Abstract]
- FASEB J. 2021 Feb;35(2):e21325. [Abstract]
- J Virol. 2025 Aug 29:e0052925. [Abstract]
- Cell Biol Int. 2025 Jul;49(7):852-864. [Abstract]
- PLoS One. 2018 Sep 20;13(9):e0203833. [Abstract]
- Blood Cells Mol Dis. 2024 Jan:104:102798. [Abstract]
- bioRxiv. 2025 March 21.
- Heliyon. 2024 May 20;10(11):e31431. [Abstract]
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Activité biologique
IC50: 23 μM (p53)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IGROV-1 | IC50 |
23 μM
Compound: PFT-beta
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Antiproliferative activity against human IGROV1 cells after 72 hrs by cell counter
Antiproliferative activity against human IGROV1 cells after 72 hrs by cell counter
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[PMID: 21324703] |
Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 60477-34-1
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Masse moléculaire 268.38
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Formule C16H16N2S
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SMILES
CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
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Synonyms
PFT β; Cyclic Pifithrin-α
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (21)
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Journal Impact Factor
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Most Recent
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Nat Commun
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. [Abstract]2025 Feb 25;16(1):1774. PMID: 40000627 -
J Immunother Cancer
Macrophage Mtdh deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production. [Abstract]2026 Feb 24;14(2):e013655. PMID: 41734995 -
Cell Commun Signal
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1. [Abstract]2022 Sep 5;20(1):96. PMID: 36058938 -
Int J Mol Med
Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation. [Abstract]2021 Jul;48(1):122. PMID: 33982778 -
Cancer Cell Int
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53. [Abstract]2023 Sep 28;23(1):221. PMID: 37770925 -
Front Bioeng Biotechnol
MiR-29c-3p Suppresses the Migration, Invasion and Cell Cycle in Esophageal Carcinoma via CCNA2/p53 Axis. [Abstract]2020 Feb 20:8:75. PMID: 32154226 -
Life Sci
Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice. [Abstract]2021 Sep 1:280:119698. PMID: 34111466 -
Cell Biol Toxicol
USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. [Abstract]2023 Oct;39(5):2011-2032. PMID: 35022897 -
Int J Mol Sci
Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. [Abstract]2023 Jul 17;24(14):11554. PMID: 37511311 -
mBio
2024 Dec 11;15(12):e0213724. PMID: 39475231 -
Front Cell Dev Biol
2020 Jul 29:8:703. PMID: 32850823 -
Sci Rep
IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma. [Abstract]2025 Sep 29;15(1):33534. PMID: 41022893 -
iScience
2024 Jun 4;27(7):110144. PMID: 38989466 -
Front Mol Biosci
2021 Aug 19;8:697457. PMID: 34490348 -
FASEB J
2021 Feb;35(2):e21325. PMID: 33508145 -
J Virol
2025 Aug 29:e0052925. PMID: 40879372 -
Cell Biol Int
2025 Jul;49(7):852-864. PMID: 40329699 -
PLoS One
2018 Sep 20;13(9):e0203833. PMID: 30235236
Pifithrin-β purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Sep 20;13(9):e0203833. [Abstract]
Western Blot analysis of TFDP3, p53 and LC3 in whole cell lysates of MDA-MB-231 transfected and treated with indicated plasmids and reagents. Cells in the treatment group are incubated with 20 μM PFT-beta for 24 hours.
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Blood Cells Mol Dis
2024 Jan:104:102798. PMID: 37813040 -
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Heliyon
HMGA2 promotes resistance against paclitaxel by targeting the p53 signaling pathway in colorectal cancer cells. [Abstract]2024 May 20;10(11):e31431. PMID: 38845972
Pureté et documentation
Références
[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [Content Brief]
[2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pifithrin-β Related Classifications
HY-16702 Related Classifications
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