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Cat. No.: HY-182721

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Pipinib

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC₅₀ of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.

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CAS No.: 2380013-55-6
Formule: C₁₇H₁₈N₄O₂S
Masse moléculaire:342.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Pipinib Chemical Structure

CAS No.: 2380013-55-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Activité biologique

Description

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In Vitro

Pipinib (0.001-10 μM; 96 h) inhibits Purmorphamine (HY-15108)-induced osteogenesis in C3H10T1/2 cells, with an IC₅₀ of 0.6 μM^[1].
Pipinib (0.01-100 μM; 48 h) inhibits GLI-mediated transcription in Shh-LIGHT2 cells, with an IC₅₀ of 1.7 μM^[1].
Pipinib (0.01-10 μM; 48 h) reduces the Purmorphamine-induced expression of Ptch1 and Gli1 in NIH/3T3 cells, with IC₅₀ values of 3.1 μM and 4.1 μM, respectively^[1].
Pipinib (5 μM; 48 h) reduces PI4P levels in NIH/3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

C3H10T1/2 mesenchymal progenitor cells
Concentration:

0.001, 0.01, 0.1, 1, 10 μM
Incubation Time:

96 h
Result:

Potently inhibited Purmorphamine-induced osteogenesis, with an IC₅₀ of 0.6 μM.

Chemical Information

CAS No. 2380013-55-6
Masse moléculaire 342.42
Formule C₁₇H₁₈N₄O₂S
SMILES

O=C(C1=CC=C(NC2=NC(NC(C)C)=NC3=C2SC=C3)C=C1)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019;58(46):16617-16628. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pipinib

Voir tous les produits spécifiques à Isoform PI4K

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Chemical Information

Pureté et documentation

Références

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Pipinib Related Classifications

HY-182721 Related Classifications