PRL 3195
PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively).
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- CAS No.: 341519-04-8
- Formule: C58H69ClN12O9S2
- Masse moléculaire:1177.83
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
|
hsst5 6 nM (Ki) |
hsst2 17 nM (Ki) |
hsst3 66 nM (Ki) |
hsst1 1000 nM (Ki) |
hsst4 1000 nM (Ki) |
rat urotensin II receptor 429 nM (Ki) |
human urotensin II receptor 1846 nM (Ki) |
PRL 3195 inhibits human urotensin II-induced phasic oscillations of rat aorta with an ED50 of 24 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 341519-04-8
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Masse moléculaire 1177.83
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Formule C58H69ClN12O9S2
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Sequence
{Phe<4Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-{Lys
}-Thr-Cys-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7) -
Sequence Shortening
{F<4Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-{K
}-TC-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7) -
Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRL 3195 Related Classifications
HY-P4469 Related Classifications
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