Procaterol
Based on 1 publication(s) in Google Scholar
Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes.
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- CAS No.: 72332-33-3
- Formule: C16H22N2O3
- Masse moléculaire:290.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Procaterol
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Activité biologique
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β2 adrenoceptor |
Procaterol (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) directly inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism[3].
Procaterol (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) Dose-dependent inhibition of RANTES release in response to IL-1b and TNF-a in BEAS-2B cell monolayers, and enhancement of GM-CSF mRNA expression in response to IL-1b[3].
Procaterol (0.1 μM, 72 h, Human tracheal surface epithelial cells) reduce rhinovirus titers and RNA, cytokine concentrations, susceptibility to rhinovirus infection, and the expression of intercellular adhesion molecule-1 (ICAM-1), the receptor for type 14 rhinovirus, and the number of acidic endosomes in the cells from which rhinovirus RNA enters into the cytoplasm[4].
Procaterol (10 nM, one time, Lung epithelial cells) increased ciliary bend amplitude (CBA) and ciliary beating frequency (CBF) in a dose dependent manner via cAMP[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:eosinophil
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Concentration:10, 100, 1000 ng/mL
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Incubation Time:24 h
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Result:Attenuated the eosinophil migratory response in a dose-dependent.
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) significantly increases weight of the levator ani muscle with anabolic effects[1].
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) increases ventral prostate weight is associated with drug stimulation of b2 adrenergic receptors in tissues[1].
Procaterol (0.03-1 mg/kg, inhalation 3 times a day, 14 days) different dose between bronchodilator and anabolic effects >30-fold, <100-fold[1].
Procaterol (0.1, 1, 10 mg/kg, orally, before ovalbumin (HY-W250978) (OVA) inhalation) inhaler does not enhance airway hyperresponsiveness, airway wall inflammation, or airway wall thickening, and decreases eosinophil number[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old rats were castrated on Day – 5, except for a normal group of 6 rats[1]
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Dosage:0.03, 0.1, 0.3, 1 mg/mL
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Administration:in-halation 3 times a day (09 : 00, 12 : 00, 16 : 00) for 14 days from Day 0 to Day 13.
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Result:No significant changed in weight or body weight gain in rat gastrocnemius muscle. Significantly increased the weight of the levator ani muscle. Increasd in ventral prostate weight.
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Animal Model:Mice immunized with ovalbumin (HY-W250978) (OVA, inhalation of 20 mg/mL OVA for 10 minutes every other day, total 7 times) + alum[2]
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Dosage:0.1, 1, 10 mg/kg
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Administration:orally, before ovalbumin (HY-W250978) (OVA) inhalation
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Result:Inhalation did not enhance airway hyperresponsiveness, airway wall inflammation, or airway wall thickening after OVA inhalation.
Reduced the number of eosinophils in BALF mice.
Chemical Information
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CAS No. 72332-33-3
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Masse moléculaire 290.36
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Formule C16H22N2O3
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SMILES
O[C@@H](C(C=C1)=C(C=CC2=O)C(N2)=C1O)[C@@H](CC)NC(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543
Pureté et documentation
Références
[1]. Ikezono K, et al. Bronchodilating effect and anabolic effect of inhaled procaterol. Int J Sports Med. 2008 Nov;29(11):888-94. [Content Brief]
[2]. Tashimo H, et al. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. [Content Brief]
[3]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [Content Brief]
[4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [Content Brief]
[5]. Komatani-Tamiya N, et al. Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. Cell Physiol Biochem. 2012;29(3-4):511-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Procaterol Related Classifications
HY-114732 Related Classifications
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