Prostaglandin E3
Based on 1 Customer Validation
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.4%
- CAS No.: 802-31-3
- Formule: C20H30O5
- Masse moléculaire:350.45
-
Stockage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-14648A
Dexamethasone acetate
-
HY-B0336
Pranoprofen
-
HY-B0577
Latanoprost
-
HY-B0601
Tafluprost acid
-
HY-125774
Bimatoprost acid
-
HY-14648AR
Dexamethasone acetate (Standard)
-
HY-135750
VAF347
-
HY-139419
Bimatoprost grenod
-
HY-130660
Prostaglandin F2α ethanolamide
-
HY-118648
Prostaglandin F2α methyl ester
-
HY-106037
PGF2α-isopropyl ester
-
HY-B0191B
Bimatoprost methyl ester
Activité biologique
Prostaglandin E3 (1-10000 nM) suppresses M1 and induces M2a marker expression in polarized macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:5 weeks, Nude mice (BABL/c) (PC3 xenograft model)[1]
-
Dosage:1 µmol/L for 50 µL
-
Administration:Injected next to the tumour, every 3 days for 4 weeks
-
Result:Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.
-
Animal Model:6-8-week-old C57BL6/J mice[1]
-
Dosage:LPS+ PGE3 (5 mg/kg + 1 µmol/L)
-
Administration:I.p.; once
-
Result:Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.
Chemical Information
-
CAS No. 802-31-3
-
Appearance Liquid
-
Masse moléculaire 350.45
-
Formule C20H30O5
-
Color Colorless to light yellow
-
SMILES
CC/C=C\C[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Solution, -20°C, 2 years
Pureté et documentation
-
Fiche technique (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Prostaglandin E3 Related Classifications
HY-113481 Related Classifications
Powered by Bioz