CD45
CD45, the leukocyte common antigen, is a receptor-type protein tyrosine phosphatase encoded by the PTPRC gene and expressed on all nucleated hematopoietic cells. Its large extracellular region is subject to alternative splicing that yields isoforms such as CD45RA on naive T cells and CD45RO on memory T cells, while cytoplasmic phosphatase domains dephosphorylate inhibitory tyrosines of the Src-family kinases Lck and Fyn, setting the threshold for T- and B-cell antigen receptor signaling. Loss-of-function PTPRC mutations cause severe combined immunodeficiency. Because isoform usage changes with lymphocyte differentiation, CD45 staining with lineage markers underpins flow-cytometric leukemia diagnosis and immunophenotyping panels.
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CD45 Protéines Recombinantes (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
