Factor H
Factor H is the dominant fluid-phase regulator of the alternative pathway: a 150-kDa plasma protein composed of twenty short consensus repeat (SCR) domains arranged in a flexible chain. Through its N-terminal SCR1-4 region it serves as a cofactor for factor I-mediated cleavage of C3b, accelerates decay of the C3bBb convertase, and distinguishes self from non-self by binding sialic acid and glycosaminoglycans on host surfaces with its C-terminal domains. Mutations or autoantibodies against factor H cause atypical hemolytic uremic syndrome and C3 glomerulopathy, and common variants modify age-related macular degeneration risk. Recombinant factor H supports these regulatory studies.
-
Factor H Protéines Recombinantes (6)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
