PSB-24379
PSB-24379 is a CD39 inhibitor that potently inhibits human membrane-bound CD39 (Ki = 77.4 nM) and truncated soluble human CD39 (Ki = 23.1 nM). PSB-24379 reduces the level of ATP hydrolysis in melanoma and breast cancer cell membranes. PSB-24379 partially reverses ATP-mediated suppression of T cell activation and proliferation in a high-ATP environment. PSB-24379 can be used in research related to melanoma and breast cancer.
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- Formule: C30H32N5O7PS
- Masse moléculaire:637.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
PSB-24379 potently inhibits both human membrane-bound CD39 (Ki = 77.4 nM) and truncated soluble human CD39 (Ki = 23.1 nM)[1].
PSB-24379 inhibits human CD73 with a Ki of 240 nM[1].
PSB-24379 reduces ATP hydrolysis activity in membrane preparations from human Ma-Mel-65 melanoma cells and human MDA-MB-231 triple-negative breast cancer cells[1].
PSB-24379 partially reverts ATP-mediated suppression of T cell activation in primary human peripheral blood mononuclear cells in an ATP-rich environment[1].
PSB-24379 exhibits high metabolic stability in human and mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 637.64
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Formule C30H32N5O7PS
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCCCCC4=CC=CC=C4)=C3N=C2SC5=C(C=CC=C6)C6=CC=C5)O[C@@H]1COP(O)(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSB-24379 Related Classifications
HY-183620 Related Classifications
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