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Cat. No.: HY-184893

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PSH18

PSH18 is a selective monoamine oxidase B (MAO-B) inhibitor with blood-brain barrier permeability, with a human-derived IC₅₀ of 0.95 μM and a K_i of 0.89 μM. PSH18 can be used for the research of Parkinson's disease.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₈H₁₃FN₄OS
Masse moléculaire:352.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSH18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

hMAO-B

0.95 μM (IC₅₀)

hMAO-B

0.89 μM (Ki)

Voir tous les produits spécifiques à Isoform Monoamine Oxidase :

MAO-A
MAO-B

In Vitro

PSH18 competes with substrates for binding to the active site of MAO-B, and forms stable active site interactions through hydrophobic interactions and π-π stacking^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 352.39
Formule C₁₈H₁₃FN₄OS
SMILES

S=C(N/N=C1C(N(CC#C)C2=C\1C=C(F)C=C2)=O)NC3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Parmbil SK, et al. Synthesis, biological evaluation and in silico studies of novel propargyl-tethered isatin hydrazones as monoamine oxidase inhibitors for Parkinson's disease. Scientific reports. 2026 Jun 19. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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PSH18

Voir tous les produits spécifiques à Isoform Monoamine Oxidase