RAFKBP12
RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
(Pink: FKBP12 ligand (HY-114434); Blue: Proteasome ligand (HY-181499); Black: linker).
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- CAS No.: 2375455-59-5
- Formule: C79H93Cl4N5O17
- Masse moléculaire:1526.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
RAFKBP12 (1-10 μM; 24 h) induces degradation of FKBP12 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells
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Concentration:1, 2.5, 10 μM
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Incubation Time:24 h
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Result:Induced degradation of FKBP12 in HEK293T cells, as detected by western blotting.
Chemical Information
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CAS No. 2375455-59-5
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Masse moléculaire 1526.42
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Formule C79H93Cl4N5O17
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SMILES
O=C([C@@H]1CCCCN1C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)O[C@@H](C3=CC=CC(OCC(NCCOCCOCCOCCC(NCCOCCN[C@H](C(N4C/C(C(/C(C4)=C/C5=CC(Cl)=C(Cl)C=C5)=O)=C\C6=CC=C(Cl)C(Cl)=C6)=O)CC7=CC=CC=C7)=O)=O)=C3)CCC8=CC(OC)=C(OC)C=C8
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RAFKBP12 Related Classifications
HY-181498 Related Classifications
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