Ravidasvir
Ravidasvir (PPI-668) is an orally active pan-genotypic NS5A inhibitor and antiviral agent. Ravidasvir exhibits antiviral activity against HCV genotypes 1 to 6, with EC50 values ranging from 0.04 to 1.14 nM. Ravidasvir shows no or extremely low activity against feline infectious peritonitis virus type II. Ravidasvir can be used in research related to hepatitis C virus infection.
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- CAS No.: 1242087-93-9
- Formule: C42H50N8O6
- Masse moléculaire:762.91
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
0.007 nM
Compound: 25
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Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
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[PMID: 24320933] |
| Huh-7 | EC50 |
0.071 nM
Compound: 25
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Antiviral activity against HCV genotype 1a H77 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
Antiviral activity against HCV genotype 1a H77 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
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[PMID: 24320933] |
In Vitro
Ravidasvir potently inhibits HCV genotypes 1 to 6 with EC50 values of 0.04 to 1.14 nM[2].
Ravidasvir (10 μM; 72 h) exhibits absent-to-minimal anti-FIPV serotype II activity and causes cytotoxicity at 10 μM in CRFK cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | AUC0-24 | AUC0-∞ | Cmax | Tmax | T1/2 | MRT0-∞ | CL/F |
|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 35 mg/kg | p.o. | 811.25 ng·h/mL | 893.09 ng·h/mL | 132.35 ng/mL | 4.00 h | 3.24 h | 5.56 h | 0.0419 |
Chemical Information
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CAS No. 1242087-93-9
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Masse moléculaire 762.91
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Formule C42H50N8O6
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SMILES
C([C@@H](NC(OC)=O)C(C)C)(=O)N1[C@H](C=2NC=3C(N2)=CC=C(C3)C4=CC5=C(C=C4)C=C(C=C5)C=6NC(=NC6)[C@H]7N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC7)CCC1
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Synonyms
PPI-668
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hefnawy M, et al. Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study. Drug Des Devel Ther. 2020;14:4377-4385. Published 2020 Oct 20. [Content Brief]
[2]. Wu G, et al. Pharmacokinetics, Safety, and Tolerability of Ravidasvir, with and without Danoprevir/Ritonavir, in Healthy Subjects. Antimicrob Agents Chemother. 2021;65(10):e0060021. [Content Brief]
[3]. Cook SE, et al. Investigation of monotherapy and combined anticoronaviral therapies against feline coronavirus serotype II in vitro. J Feline Med Surg. 2022;24(10):943-953. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ravidasvir Related Classifications
HY-17619 Related Classifications
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