Reltecimod sodium
Reltecimod sodium (AB-103 sodium) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod sodium has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod sodium modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod sodium can be used to research necrotizing soft-tissue infections (NSTIs).
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- CAS No.: 1943755-99-4
- Formule: C46H71N10NaO15S
- Masse moléculaire:1059.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration with E. coli 018:K1)[2]
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Dosage:1.25 or 5 mg/kg
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Administration:i.v.; single dosage; at 4 h post infection
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Result:Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6.
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Animal Model:Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration with Streptococcus pyogenes)[2]
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Dosage:2.5 or 5 mg/kg
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Administration:i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection
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Result:Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6.
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Animal Model:Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2]
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Dosage:1.25, 2.5, or 5 mg/kg
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Administration:i.v.; single dosage
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Result:Increased day 7 survival by up to 100%.
Chemical Information
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CAS No. 1943755-99-4
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Masse moléculaire 1059.17
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Formule C46H71N10NaO15S
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Synonyms
AB-103 sodium
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Sequence
{d-Ala}-Ser-Pro-Met-Leu-Val-Ala-Tyr-Asp-{d-Ala}
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Sequence Shortening
{d-Ala}-SPMLVAYD-{d-Ala}
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Reltecimod sodium Related Classifications
HY-P1698A Related Classifications
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