Reverse transcriptase-IN-3
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains.
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- CAS No.: 3037989-21-9
- Formule: C28H31N7O4S
- Masse moléculaire:561.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HIV (IIIB) 8 nM (EC50) |
HIV-1 (L100I) 65 nM (EC50) |
HIV-1 (K103N) 9 nM (EC50) |
HIV-1 (Y181C) 45 nM (EC50) |
HIV-1 (Y188L) 35 nM (EC50) |
HIV-1 (E138K) 0.734 μM (EC50) |
HIV-1 (F227L+V106A) 34 nM (EC50) |
HIV-1 (RES056) 42 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| MT4 | CC50 |
208 μM
Compound: 21c
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Cytotoxicity against human MT4 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 36446205] |
Reverse transcriptase-IN-3 (compound 21c) exhibits the most potent activity (EC50=0.009-0.065 μM) against HIV-1 IIIB (8 nM), L100I (65 nM), K103N (9 nM), Y181C (45 nM), Y188L (35 nM), and RES056 (42 nM), being comparable of Etravirine (HY-90005)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3037989-21-9
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Masse moléculaire 561.66
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Formule C28H31N7O4S
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SMILES
CC1=CC(C#N)=CC(C)=C1OC2=C(C=NC(NC3CCN(CC3)C4=CC=C(C=C4)NS(=O)(C5CC5)=O)=N2)C(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Reverse transcriptase-IN-3 Related Classifications
HY-151938 Related Classifications
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