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Cat. No.: HY-118285

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Ro4491533

Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.

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CAS No.: 579482-31-8
Formule: C₂₄H₂₀F₃N₃O
Masse moléculaire:423.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Ro4491533 Chemical Structure

CAS No.: 579482-31-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	<0.01 μM Compound: 7am	Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]
CHO	IC₅₀	<0.01 μM Compound: 7am	Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]
CHO	IC₅₀	0.003 μM Compound: 7am	Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production	[PMID: 20971004]
CHO	IC₅₀	0.014 μM Compound: 7am	Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current	[PMID: 20971004]

Chemical Information

CAS No. 579482-31-8
Masse moléculaire 423.43
Formule C₂₄H₂₀F₃N₃O
SMILES

O=C1NC2=CC(C(F)(F)F)=C(C=C2N=C(C1)C3=CC=CC(C4=CC(C)=NC(C)=C4)=C3)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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