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Cat. No.: HY-163384

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(S)-CE-123

(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC₅₀ of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals.

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CAS No.: 2378384-49-5
Formule: C₁₇H₁₅NOS₂
Masse moléculaire:313.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(S)-CE-123 Chemical Structure

CAS No.: 2378384-49-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Solvant et solubilité
- In Vivo
Pureté et documentation
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Activité biologique

Description

In Vivo

(S)-CE-123 (6.0, 12.0, 24.0 mg/kg; ip; 30 min before testing) significantly attenuates the effects of TBZ (Tetrabenazine; HY-B0590) on lever pressing and chow intake. (S)-CE-123 alone has no significant difference with vehicle-treated rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Trained rats (adult male Sprague-Dawley rats)^[1]
Dosage:

6.0, 12.0, 24.0 mg/kg
Administration:

IP; 30 min before testing
Result:

Attenuated the effects of TBZ (1.0 mg/kg) on lever pressing and chow intake.

Chemical Information

CAS No. 2378384-49-5
Masse moléculaire 313.44
Formule C₁₇H₁₅NOS₂
SMILES

O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvant et solubilité

View the Complete Stock Solution Preparation Table

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

10% DMSO +15%Tween 80 +75% 0.9% saline

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. [Content Brief]

[2]. Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S)-CE-123. ACS Omega 2024, March 4.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vivo
Chemical Information
Solvant et solubilité
- In Vivo
Pureté et documentation
Références

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(S)-CE-123

High-Throughput Bioactive Compound Library