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Cat. No.: HY-130558

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SL-1-73

SL-1-73 is a tubulin ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2000199-44-8
Formule: C₂₀H₁₉N₃O₅S
Masse moléculaire:413.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SL-1-73 Chemical Structure

CAS No.: 2000199-44-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	1.83 μM Compound: 13k	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.096 μM Compound: 13k	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
KYSE-140	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-30	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-410	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-510	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
MCF7	IC₅₀	0.45 μM Compound: 13k	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	IC₅₀	0.43 μM Compound: 13k	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]

Chemical Information

CAS No. 2000199-44-8
Masse moléculaire 413.45
Formule C₂₀H₁₉N₃O₅S
SMILES

O=S(NC1=CC=C(OC)N=C1OC)(C2=CC(C3=CC(O)=CC=C3N4C)=C4C=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Niu F, et al. Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma. Cancer Lett. 2018 Apr 28;420:60-71. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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