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Cat. No.: HY-122566

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SMU127

(Synonyms: ZINC666243)

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC₅₀=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

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CAS No.: 903864-87-9
Formule: C₁₆H₂₃N₃O₃S
Masse moléculaire:337.44

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Data Sheet (268 KB)

SMU127 Chemical Structure

CAS No.: 903864-87-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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Chemical Information

CAS No. 903864-87-9
Masse moléculaire 337.44
Formule C₁₆H₂₃N₃O₃S
SMILES

O=C(C1=C(NC(N2CCN(C)CC2)=O)SC3=C1CCC3)OCC
Synonyms

ZINC666243
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen, et al. Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library database. Chem. Commun. (Camb.) 54(81), 11411-11414 (2018).

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100 mg

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Chemical Information
Pureté et documentation
Références

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SMU127

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR)

Voir tous les produits spécifiques à Isoform TNF Receptor