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Cat. No.: HY-189759

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SQ-030

SQ-030 is a cPGES inhibitor with a human K_d of 0.315 μM. SQ-030 reduces lipid accumulation in hepatocytes. SQ-030 ameliorates hepatic dysfunction, hepatic steatosis, inflammation, and fibrosis in mice. SQ-030 alleviates hepatic dysfunction and lipid deposition in mice. SQ-030 can be used for research on metabolic dysfunction-associated steatotic liver disease (MASLD).

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CAS No.: 667880-05-9
Formule: C₂₁H₂₁N₃O₅
Masse moléculaire:395.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

SQ-030 Chemical Structure

CAS No.: 667880-05-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

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In Vitro

Lipid Metabolism

SQ-030 (PA + OA: 0.6 mM palmitate + 0.3 mM oleate; 24 h) reduces lipid accumulation in PA + OA-treated AML12 mouse hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityLipid Inflammatory MediatorsLipid Metabolism

Innate Immunity

Lipid Inflammatory Mediators

Lipid Metabolism

SQ-030 (1 mg/kg; i.p.; every other day; 4 weeks) ameliorates methionine-choline-deficient (MCD) diet-induced metabolic dysfunction-associated steatohepatitis (MASH), attenuating liver injury, steatosis, inflammation, and fibrosis without altering hepatic PGE₂-EP receptor signaling^[1].

Lipid Metabolism

SQ-030 alleviates high-fat diet (HFD)-induced hepatic dysfunction and lipid deposition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male)^[1]
Dosage:

1 mg/kg
Administration:

i.p.; every other day; for 4 weeks
Result:

Alleviated liver dysfunction (serum AST and ALT), hepatic steatosis, inflammation, and fibrosis.
Relative NAS was lower in SQ-030-treated MCD mice than in controls.
Did not change hepatic PGE2 levels or mRNA expression of the four EP receptors (Ptger1-4).

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Chemical Information

CAS No. 667880-05-9
Masse moléculaire 395.41
Formule C₂₁H₂₁N₃O₅
SMILES

CC1=C(C(OC)=O)C(C2=CC=C(OCC(NC3=CC=CC=C3)=O)C=C2)NC(N1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhong D, et al. Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression. Cell reports. 2026 Sep 22;45(9):117901.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SQ-030

Voir tous les produits spécifiques à Isoform HSP

Activité biologique

Description

In Vitro

In Vivo

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SQ-030 Related Classifications

HY-189759 Related Classifications

Bioz

Keywords

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