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Cat. No.: HY-184379

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SRI-37264

SRI-37264 is a HIV-1 Nef inhibitor with a K_d value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection.

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CAS No.: 2358714-71-1
Formule: C₁₇H₁₄ClN₃O₃S
Masse moléculaire:375.83

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Please store the product under the recommended conditions in the Certificate of Analysis.

SRI-37264 Chemical Structure

CAS No.: 2358714-71-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
- Parmacokinetics
Chemical Information
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Activité biologique

Description

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In Vitro

SRI-37264 (3-48 h) inhibits Nef-dependent HIV-1 infectivity in TZM-bl cells with an IC₅₀ of 0.32 μM and has no detectable cytotoxicity (CC₅₀ > 100 μM)^[1].
SRI-37264 (1.0 μM; 24 h) partially restores cell-surface MHC-I expression by 15.9% in HIV-1-infected primary HLA-A2⁺ CD8-depleted PBMCs^[1].
SRI-37264 (125 μM; 25 min) at a 5-fold molar excess disrupts preformed recombinant Nef-CD·AP-1 μ1 complexes in solution^[1].
SRI-37264 has excellent metabolic stability with a half-life > 2 h in mouse and human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2
Mice^[1]	1 mg/kg	i.v.	40 min

Chemical Information

CAS No. 2358714-71-1
Masse moléculaire 375.83
Formule C₁₇H₁₄ClN₃O₃S
SMILES

O=C1C2=CC=CN=C2SN1C3=CC=C(C(C(N4CCOCC4)=O)=C3)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Emert-Sedlak LA, et al. Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. ACS infectious diseases. 2022 Jan 14;8(1):91-105. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SRI-37264

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SRI-37264 Related Classifications

HY-184379 Related Classifications